Weber-Christian disease is a relapsing, febrile, nodular, nonsuppurative inflammation of the subc utaneous fat tissue. Many authors reported these cases which illustrate the.great variability of the clinical manifestaion, such as acute or chronic, fulminating or transient, febrile or non febrile, syst emic or cutaneous. ´
Two of our cases have had recurrent painful subcutaneous nodules without fever for several years. Biopsy showed a nonspecific inflammatory panniculitis with lymphocytes chiefly, and small amount of histiocytes and foamy cells. It should be suggested Weber-Chritian disease when subcutaneous nodules appear recurrently some aitas of the whole body surface except anterior aspects of tibia even if no fever as systemic manifestation. Treatmar_t with steroid and chloroquine diphosphate produced good improvement.
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